Protein Phosphatase 1 Recruitment by Rif1 Regulates DNA Replication Origin Firing by Counteracting DDK Activity
The firing of Round Inserts eukaryotic origins of DNA replication requires CDK and DDK kinase activities.DDK, in particular, is involved in setting the temporal program of origin activation, a conserved feature of eukaryotes.Rif1, originally identified as a telomeric protein, was recently implicated in specifying replication timing in yeast and mam