PROTEIN PHOSPHATASE 1 RECRUITMENT BY RIF1 REGULATES DNA REPLICATION ORIGIN FIRING BY COUNTERACTING DDK ACTIVITY

Protein Phosphatase 1 Recruitment by Rif1 Regulates DNA Replication Origin Firing by Counteracting DDK Activity

The firing of Round Inserts eukaryotic origins of DNA replication requires CDK and DDK kinase activities.DDK, in particular, is involved in setting the temporal program of origin activation, a conserved feature of eukaryotes.Rif1, originally identified as a telomeric protein, was recently implicated in specifying replication timing in yeast and mam

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Imperfect twinning: a clinical and ethical dilemma

OBJECTIVE To review the history, epidemiology, etiology, gestational aspects, diagnosis and prognosis of imperfect twinning.DATA SOURCES Scientific articles were ALKALINE PITCHER WHITE searched in PubMed, SciELO and Lilacs databases, using the descriptors "conjoined twins", "multiple pregnancy", "ultrasound", "magnetic resonance imaging" and "progn

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